发明申请
- 专利标题： SULFANYL SUBSTITUTED PHENYL METHANONES
- 专利标题（中）： SULFANYL替代苯甲醇
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申请号： US12173886申请日： 2008-07-16
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公开(公告)号： US20080287455A1公开(公告)日： 2008-11-20
- 发明人: Synese Jolidon , Robert Narquizian , Roger David Norcross , Emmanuel Pinard
- 申请人： Synese Jolidon , Robert Narquizian , Roger David Norcross , Emmanuel Pinard
- 优先权： EP05100066.9 20050106
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; C07D295/00 ; A61K31/495 ; A61P25/18 ; C07D403/02 ; C07D401/02
摘要：
The present invention relates to compounds of formula I wherein R1, R2, R3, X, X1, and n are as defined in the specification and pharmaceutically acceptable acid addition salts thereof. These compounds are good inhibitors of the glycine transporter 1 (GlyT-1) for the treatment CNS disorders, such as schizophrenia, cognitive impairment, and Alzheimer's disease.
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