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发明申请
US20080287496A1 1-Oxo- and 1,3-dioxoisoindolines and method of reducing inflammatory cytokine levels 审中-公开
1-氧代和1,3-二氧代异吲哚啉和减少炎症细胞因子水平的方法

1-Oxo- and 1,3-dioxoisoindolines and method of reducing inflammatory cytokine levels
摘要：
1-Oxo- and 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindolines substituted in the 4- and/or 7-position of the isoindoline ring and optionally further substituted in the 3-position of the 2,6-dioxopiperidine ring reduce the levels of inflammatory cytokines such as TNFα in a mammal. A typical embodiment is 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline
摘要（中）：

在异二氢吲哚环的4-和/或7-位取代的1-氧代 - 和1,3-二氧代-2-（2,6-二氧代哌啶-3-基）异吲哚啉，并任选进一步在3- 2,6-二氧代哌啶环降低哺乳动物炎症细胞因子如TNFα的水平。 典型的实施方案是1,3-二氧代-2-（2,6-二氧代哌啶-3-基）-4-甲基异吲哚啉

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