Invention Application
US20080292550A1 Fluorinated 3'-Deoxythymidine Derivatives, a Method for Their Preparation and Their Use
审中-公开
氟化3'-脱氧胸苷衍生物，其制备方法及其应用
- Patent Title: Fluorinated 3'-Deoxythymidine Derivatives, a Method for Their Preparation and Their Use
- Patent Title (中): 氟化3'-脱氧胸苷衍生物，其制备方法及其应用
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Application No.: US11912425Application Date: 2006-04-25
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Publication No.: US20080292550A1Publication Date: 2008-11-27
- Inventor: Dieter Baerwolff , Rolf Lindner , Dieter-Ludwig Munz , Rainer Michael
- Applicant: Dieter Baerwolff , Rolf Lindner , Dieter-Ludwig Munz , Rainer Michael
- Applicant Address: DE Berlin DE Berlin
- Assignee: MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN,CHARITE UNIVERSITAETSMEDIZIN BERLIN
- Current Assignee: MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN,CHARITE UNIVERSITAETSMEDIZIN BERLIN
- Current Assignee Address: DE Berlin DE Berlin
- Priority: DE102005019452.4 20050425
- International Application: PCT/EP2006/004228 WO 20060425
- Main IPC: A61K51/00
- IPC: A61K51/00 ; C07H19/067 ; A61K31/706
Abstract:
The invention relates to new side chain-fluorinated 3′-deoxythymidine derivatives of the general formula I or physiological acceptable esters thereof, wherein R═CH218F; CH18F2; CH2F or CHF2 and Y═H, N3 or Hal. The invention also relates to a simple and efficient method for the preparation of these 3′-deoxythymidines of formula I and to the use of the 18F-containing compounds of formula I or of a pharmaceutical composition comprising these compounds for the diagnosis of tumors in positron emission tomography (PET).
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