发明申请
US20080293579A1 Crystal structure of polo-like kinase 3 (PLK3) and binding pockets thereof
失效
polo样激酶3（PLK3）的结构结构及其结合口袋
- 专利标题： Crystal structure of polo-like kinase 3 (PLK3) and binding pockets thereof
- 专利标题（中）： polo样激酶3（PLK3）的结构结构及其结合口袋
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申请号： US11818698申请日： 2007-06-14
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公开(公告)号： US20080293579A1公开(公告)日： 2008-11-27
- 发明人: Kieron Brown , Graham MT Cheetham , Suzanne B. Renwick , Joanna M. Long
- 申请人： Kieron Brown , Graham MT Cheetham , Suzanne B. Renwick , Joanna M. Long
- 主分类号： C40B30/02
- IPC分类号： C40B30/02 ; C12N9/12 ; G06G7/48 ; C40B30/08
摘要：
The invention relates to molecules or molecular complexes, which comprise binding pockets of PLK3 or its structural homologues. The invention relates to crystallizable compositions and crystals comprising PLK3. The present invention also relates to a data storage medium encoded with the structural coordinates of molecules and molecular complexes which comprise the PLK3 or PLK3-like ATP-binding pockets. The present invention also relates to a computer comprising such data storage material. The computer may generate a three-dimensional structure or graphical three-dimensional representation of such molecules or molecular complexes. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for, identify and design compounds, including inhibitory compounds that bind to PLK3 or homologues thereof.
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