发明申请
US20080293767A1 1-Isopropyl-2-Oxo-1,2-Dihydropyridine-3-Carboxamide Derivatives Having 5-Ht4 Receptor Agonistic Activity
失效
具有5-Ht4受体激动活性的1-异丙基-2-氧代-1,2-二氢吡啶-3-甲酰胺衍生物
- 专利标题: 1-Isopropyl-2-Oxo-1,2-Dihydropyridine-3-Carboxamide Derivatives Having 5-Ht4 Receptor Agonistic Activity
- 专利标题(中): 具有5-Ht4受体激动活性的1-异丙基-2-氧代-1,2-二氢吡啶-3-甲酰胺衍生物
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申请号: US10597480申请日: 2005-01-18
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公开(公告)号: US20080293767A1公开(公告)日: 2008-11-27
- 发明人: Tomoki Kato , Kiyoshi Kawamura , Chikara Uchida
- 申请人: Tomoki Kato , Kiyoshi Kawamura , Chikara Uchida
- 国际申请: PCT/IB2005/000173 WO 20050118
- 主分类号: A61K31/4545
- IPC分类号: A61K31/4545 ; A61P3/00 ; A61P25/00 ; A61P1/00 ; A61P9/00 ; C07D405/14 ; C07D401/12
摘要:
This invention provides a compound of formula (I): wherein R1 represents an alkyl group having from 1 to 4 carbon atoms or a halogen atom, R2 represents an alkyl group having from 1 to 4 carbon atoms, R3 represents a hydrogen atom or a hydroxy group, and A represents an oxygen atom or a group of the formula —C(R4)(R5)— (in which R4 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms and R5 represents a hydroxy group or an alkoxy group having from 1 to 4 carbon atoms) or a pharmaceutically acceptable salts thereof. These compounds have 5-HT4 receptor agonistic activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans.
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