Invention Application
US20080300389A1 Metal-polysaccharide conjugates: compositions, synthesis and methods for cancer therapy
审中-公开
金属 - 多糖共轭物:用于癌症治疗的组合物,合成和方法
- Patent Title: Metal-polysaccharide conjugates: compositions, synthesis and methods for cancer therapy
- Patent Title (中): 金属 - 多糖共轭物:用于癌症治疗的组合物,合成和方法
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Application No.: US12009421Application Date: 2008-01-18
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Publication No.: US20080300389A1Publication Date: 2008-12-04
- Inventor: David J. Yang , Dong-Fang Yu , I-Chien Wei
- Applicant: David J. Yang , Dong-Fang Yu , I-Chien Wei
- Main IPC: C07H15/00
- IPC: C07H15/00

Abstract:
The current disclosure, in one embodiment, includes a polysaccharide conjugate. This conjugate has a polysaccharide and at least one monomeric amino acid having an O-group covalently bound to the polysaccharide. The conjugate also has at least one metal conjugated by the O-group of the amino acid. According to another embodiment, the disclosure provides a method of synthesizing a polysaccharide conjugate by covalently bonding a monomeric amino acid having an O-group to a polysaccharide and by conjugating a metal to the O-group to form a polysaccharide conjugate. According to a third embodiment, the disclosure relates to a method of killing a cancer cell by administering to the cell an effective amount of a polysaccharide conjugate. This conjugate has a polysaccharide and at least one monomeric amino acid having an O-group covalently bound to the polysaccharide. The conjugate also has at least one metal conjugated by the O-group of the amino acid.
Information query