A digital image capture and processing system supporting automatic communication interface testing/detection and system configuration parameter programming. The digital image capture and processing system includes a housing having a port for receiving a standard connector associated with a flexible communication interface cable, and a multi-interface I/O subsystem disposed in the housing, and having an I/O port. The multi-interface I/O subsystem supports a software-controlled automatic communication interface test/detection process carried out over the flexible communication interface cable physically connecting the I/O ports of the digital image capture and processing subsystem and the designated host system. The digital image capture and processing system also supports automatic programming of multiple system configuration parameters (SCPs), associated with a particular communication interface (CI) detected by the multi-interface I/O subsystem, without reading programming-type bar codes.