发明申请
- 专利标题： AMPLIFICATION OF HUMAN MDM2 GENE IN HUMAN TUMORS
- 专利标题（中）： 人MDM2基因在人肿瘤中的扩增
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申请号： US12165697申请日： 2008-07-01
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公开(公告)号： US20080305490A1公开(公告)日： 2008-12-11
- 发明人: Marilee Burrell , David E. Hill , Kenneth W. Kinzler , Bert Vogelstein
- 申请人： Marilee Burrell , David E. Hill , Kenneth W. Kinzler , Bert Vogelstein
- 申请人地址： US MD Baltimore
- 专利权人： The Johns Hopkins University
- 当前专利权人： The Johns Hopkins University
- 当前专利权人地址： US MD Baltimore
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12N15/11 ; C07K14/47 ; C07K16/32 ; C12N15/12 ; C12N5/08 ; C12N5/22 ; A61P35/00
摘要：
A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MD2 protein binds to human p53 and allows the cell to escape from p53-regulated growth.
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