A system for and method of calibrating an imaging device efficiently is described herein. The imaging device acquires an image of an object that is more than one color. The information acquired is then transferred to a computing device. The information is then used to generate a set of data which represents information which was not acquired in the image. The set of data is generated based on statistical prediction using a training data set. Using acquired image information and the set of data, an imaging device is able to be calibrated. Since the process of calibration utilizing this method only requires one image to be acquired and a reduced set of image information to be sent to the computing device, the process is more efficient than previous implementations.