A method of driving a CCD solid-state image pickup device, which performs multiplication driving on the signal charges, the method including: reading out signal charges from a plurality of photoelectric converting elements that are arranged in a two-dimensional array-like pattern to a charge transfer path that is disposed in parallel to a photoelectric converting element column of the photoelectric converting elements; and applying a multiplying pulse to a multiplying electrode among transfer electrodes constituting the charge transfer path, wherein an electrode, which is set as the multiplying electrode among the transfer electrodes, is periodically changed.