发明申请
US20080311635A1 PROCESS FOR THE PREPARATION OF (S)(+)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID
审中-公开
（S）（+） - 3-（氨基甲酰基）-5-甲基六氢叶酸的制备方法
- 专利标题： PROCESS FOR THE PREPARATION OF (S)(+)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID
- 专利标题（中）： （S）（+） - 3-（氨基甲酰基）-5-甲基六氢叶酸的制备方法
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申请号： US12119967申请日： 2008-05-13
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公开(公告)号： US20080311635A1公开(公告)日： 2008-12-18
- 发明人: Sergio Riva , Pietro Allegrini , Elena Serafini , Gabriele Razzetti , Simone Mantegazza , Dario Pastorello
- 申请人： Sergio Riva , Pietro Allegrini , Elena Serafini , Gabriele Razzetti , Simone Mantegazza , Dario Pastorello
- 申请人地址： IT Baranzate
- 专利权人： DIPHARMA FRANCIS s.r.l.
- 当前专利权人： DIPHARMA FRANCIS s.r.l.
- 当前专利权人地址： IT Baranzate
- 优先权： ITMI2007A971 20070514; ITMI2007A1722 20070905; ITMI2008A318 20080228
- 主分类号： C12P13/00
- IPC分类号： C12P13/00 ; C07C271/10 ; C07C229/02
摘要：
A process for the preparation of (S)(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) of formula (I) or a salt thereof, comprising the reaction of a compound of formula (II) with an alcohol ROH, in the presence or absence of enzyme, to give a compound of formula (III) as herein defined the transformation of a compound of formula (III) into a compound of formula (VI) or (VIII) as herein defined, and the subsequent hydrolysis of a compound of formula (VI) or (VIII), to give pregabalin.
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