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发明申请
US20080314817A1 Direct Hemoperfusion Adsorber Packed with Adsorbent Having Water Insoluble Microparticle Removed Therefrom, and Method of Obtaining Direct Hemoperfusion Adsorbent Having Water Insoluble Microparticle Removed Therefrom 有权
直接血液灌注吸附剂，其中吸附有不溶于水的微粒被除去的吸附剂，以及从其中除去具有水不溶性微粒的直接血液灌注吸附剂的方法

  • 专利标题： Direct Hemoperfusion Adsorber Packed with Adsorbent Having Water Insoluble Microparticle Removed Therefrom, and Method of Obtaining Direct Hemoperfusion Adsorbent Having Water Insoluble Microparticle Removed Therefrom
  • 专利标题（中）： 直接血液灌注吸附剂，其中吸附有不溶于水的微粒被除去的吸附剂，以及从其中除去具有水不溶性微粒的直接血液灌注吸附剂的方法
  • 申请号： US11572542
    申请日： 2005-07-20
  • 公开(公告)号： US20080314817A1
    公开(公告)日： 2008-12-25
  • 发明人: Koji Fujita , Masaru Nakatani , Akira Kobayashi , Takehiro Nishimoto
  • 申请人： Koji Fujita , Masaru Nakatani , Akira Kobayashi , Takehiro Nishimoto
  • 申请人地址： JP Kita-ku, Osaka-shi
  • 专利权人： Kaneka Corporation
  • 当前专利权人： Kaneka Corporation
  • 当前专利权人地址： JP Kita-ku, Osaka-shi
  • 优先权： JP2004-215411 20040723
  • 国际申请： PCT/JP2005/013328 WO 20050720
  • 主分类号： A61M1/36
  • IPC分类号： A61M1/36 ;  A61L33/00 ;  B01J20/28
Direct Hemoperfusion Adsorber Packed with Adsorbent Having Water Insoluble Microparticle Removed Therefrom, and Method of Obtaining Direct Hemoperfusion Adsorbent Having Water Insoluble Microparticle Removed Therefrom
摘要：
The present invention has its object to provide a direct hemoperfusion adsorber packed with an adsorbent made by using a water-insoluble carrier having a relatively readily available particle size distribution, with water-insoluble microparticles having been removed therefrom, without needing any special granulation apparatus or coating apparatus, and method of obtaining a direct hemoperfusion adsorbent having water-insoluble microparticles removed therefrom.Now, a direct hemoperfusion adsorber has been obtained that is packed with an adsorbent having a number average particle diameter of not smaller than 300 μm but not larger than 600 μm, with the coefficient of variance in particle diameter distribution being not lower than 10% but not higher than 20%, and having water-insoluble microparticles removed therefrom to a safe level, without the loss of the adsorbent, by using a water-insoluble microparticle-removing-mesh such that the ratio of the mesh opening size for removing water-insoluble microparticles to the mesh opening size of the adsorber is not lower than 1.3 but not higher than 1.5.
摘要（中）：

本发明的目的是提供一种直接血液灌注吸附器，其中填充有通过使用具有相对容易获得的粒度分布的水不溶性载体制备的吸附剂，其中不溶性微粒被除去，不需要任何特殊的造粒装置或 涂布装置以及从其中除去具有水不溶性微粒的直接血液灌注吸附剂的方法。 现在，已经获得了填充数均粒径不小于300μm但不大于600μm的吸附剂的直接血液灌注吸附器，其粒径分布的变异系数不低于10％，但是 不高于20％，并且通过使用不溶于水的微粒去除网，使除去水溶性微粒的网孔尺寸的比例，将水不溶性微粒除去，达到安全水平，而不损失吸附剂， 不溶性微粒与吸附剂的网孔尺寸不小于1.3，但不高于1.5。

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