发明申请
- 专利标题: Inhibition of Infiltration, and Cell Killing Agent
- 专利标题(中): 抑制渗透和细胞杀伤剂
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申请号: US11630759申请日: 2005-06-23
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公开(公告)号: US20080318297A1公开(公告)日: 2008-12-25
- 发明人: Mitsuru Nakamura , Jiro Kikuchi , Chizu Nonomura , Hidenobu Ando
- 申请人: Mitsuru Nakamura , Jiro Kikuchi , Chizu Nonomura , Hidenobu Ando
- 优先权: JP2004-184583 20040623
- 国际申请: PCT/JP2005/011560 WO 20050623
- 主分类号: C12N9/24
- IPC分类号: C12N9/24 ; C07H21/02 ; C07K16/28 ; C07K16/46 ; C07H3/00 ; C12N5/06
摘要:
As suppressor of binding between selectin binding sugar chain and selectin or cell killing agent, (1) siRNA suppressing expression of genes which relates to cell surface antigen CD43 and selectin ligand sugar chain by RNA interference; (2) an inhibitor of sugar chain synthesis such as analogue of substrates in sugar chain synthesis; (3) an enzyme severing cell surface antigen CD43 and selectin ligand sugar chain; and (4) antibodies of cell surface antigen CD43 and selectin ligand sugar chain are used to selectin ligand sugar chain expressed in cell surface antigen CD43 to provide a suppressor of infiltration which is able to suppression of infiltration to tissues by leukocytes and a method of suppression thereof, and a cell killing agent of CD43 expressing cell and a cell killing method thereof.