发明申请
- 专利标题： Substituted monocyclic CGRP receptor antagonists
- 专利标题（中）： 取代的单环CGRP受体拮抗剂
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申请号： US12214460申请日： 2008-06-19
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公开(公告)号： US20080318927A1公开(公告)日： 2008-12-25
- 发明人: Michael R. Wood , Steven N. Gallicchio , Harold G. Selnick , C. Blair Zartman , Ian M. Bell , Craig A. Stump
- 申请人： Michael R. Wood , Steven N. Gallicchio , Harold G. Selnick , C. Blair Zartman , Ian M. Bell , Craig A. Stump
- 主分类号： A61K31/551
- IPC分类号： A61K31/551 ; A61K31/454 ; C07D401/12 ; A61K31/541 ; A61P25/06 ; A61K31/501 ; A61K31/496 ; C07D417/12 ; C07D471/04
摘要：
Compounds of formula I: (wherein variables A1, A2, A2, A4, m, n, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
公开/授权文献
- US07625901B2 Substituted monocyclic CGRP receptor antagonists 公开/授权日：2009-12-01