发明申请
- 专利标题: Di-amino-substituted heterocyclic compounds and methods of use
- 专利标题(中): 二氨基取代的杂环化合物及其使用方法
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申请号: US11879832申请日: 2007-07-18
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公开(公告)号: US20080318946A1公开(公告)日: 2008-12-25
- 发明人: Ning Chen , Essa Hu
- 申请人: Ning Chen , Essa Hu
- 申请人地址: US CA Thousand Oaks
- 专利权人: AMGEN INC.
- 当前专利权人: AMGEN INC.
- 当前专利权人地址: US CA Thousand Oaks
- 主分类号: A61K31/506
- IPC分类号: A61K31/506 ; C07D413/14 ; A61P37/02 ; A61K31/5377 ; A61P35/00
摘要:
The present invention comprises a new class of compounds capable of modulating the c-kit receptor and, accordingly, useful for treatment of c-kit mediated diseases, including various fibrotic and mast cell related diseases such as mastocytosis. The compounds have a general Formula I wherein R1-6, X and Y are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of c-kit mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
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