发明申请
- 专利标题： Novel Glucitol Derivative, Prodrug Thereof And Salt Thereof, And Therapeutic Agent Containing The Same For Diabetes
- 专利标题（中）： 新型葡萄糖醇衍生物，其药物及其盐，以及含有糖尿病的治疗剂
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申请号： US11658765申请日： 2005-07-27
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公开(公告)号： US20080319047A1公开(公告)日： 2008-12-25
- 发明人: Hiroharu Matsuoka , Tsutomu Sato , Masahiro Nishimoto , Yasuharu Kato , Masahiro Sakaitani , Sang-Hak Lee
- 申请人： Hiroharu Matsuoka , Tsutomu Sato , Masahiro Nishimoto , Yasuharu Kato , Masahiro Sakaitani , Sang-Hak Lee
- 优先权： JP2004-343942 19941129; JP2004-218895 20040727
- 国际申请： PCT/JP05/13716 WO 20050727
- 主分类号： C07D409/10
- IPC分类号： C07D409/10 ; A61K31/381 ; A61P3/10
摘要：
The invention provides a glucitol derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): wherein m is an integer selected among 1-3; R1 to R4 each independently is optionally substituted alkyl, etc.; Ar1 is optionally substituted naphthyl; and A is optionally substituted heteroaryl, a prodrug of the compound, or a pharmaceutically acceptable salt of either. Also provided are a medicine, a medicinal composition, and the like each containing the compound.