发明申请
US20080319201A1 N[S(4-ARYL-TRIAZOL-3-YL)alpha-MERCAPTOACETYL] -P-AMINO BENZOIC ACIDS AS HIV REVERSE TRANSCRIPTASE INHIBITORS
有权
N [S（4-ARYL-TRIAZOL-3-YL）α-MERCAPTOACETYL] -P-氨基苯甲酸作为HIV逆转录酶抑制剂
![N[S(4-ARYL-TRIAZOL-3-YL)alpha-MERCAPTOACETYL] -P-AMINO BENZOIC ACIDS AS HIV REVERSE TRANSCRIPTASE INHIBITORS](/docs/US/2008-12-25/US20080319201A1/abs.jpg.600x600.jpg)
- 专利标题： N[S(4-ARYL-TRIAZOL-3-YL)alpha-MERCAPTOACETYL] -P-AMINO BENZOIC ACIDS AS HIV REVERSE TRANSCRIPTASE INHIBITORS
- 专利标题（中）： N [S（4-ARYL-TRIAZOL-3-YL）α-MERCAPTOACETYL] -P-氨基苯甲酸作为HIV逆转录酶抑制剂
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申请号： US12193599申请日： 2008-08-18
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公开(公告)号： US20080319201A1公开(公告)日： 2008-12-25
- 发明人: Jean-Luc Girardet , Yung-hyo Koh , Martha de la Rosa , Zhi Hong , Stanley Lang
- 申请人： Jean-Luc Girardet , Yung-hyo Koh , Martha de la Rosa , Zhi Hong , Stanley Lang
- 申请人地址： US CA San Diego
- 专利权人： Ardea Biosciences, Inc., a California Corporation
- 当前专利权人： Ardea Biosciences, Inc., a California Corporation
- 当前专利权人地址： US CA San Diego
- 主分类号： C07D249/12
- IPC分类号： C07D249/12
![N[S(4-ARYL-TRIAZOL-3-YL)alpha-MERCAPTOACETYL] -P-AMINO BENZOIC ACIDS AS HIV REVERSE TRANSCRIPTASE INHIBITORS](/abs-image/US/2008/12/25/US20080319201A1/abs.jpg.150x150.jpg)
摘要：
A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives. are provided, where Q is CO2H, or a salt or ester thereof, or a C(O) N-linked amino acid. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.
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