发明申请
US20090005388A1 3-Heteroaryl-3,9-Diazabicyclo[3.3.1]Nonane Derivatives as Nicotinic Acetylcholine Receptor Agonists
有权
3-杂芳基-3,9-二氮杂双环[3.3.1]壬烷衍生物作为烟碱乙酰胆碱受体激动剂
![3-Heteroaryl-3,9-Diazabicyclo[3.3.1]Nonane Derivatives as Nicotinic Acetylcholine Receptor Agonists](/docs/US/2009-01-01/US20090005388A1/abs.jpg.600x600.jpg)
- 专利标题： 3-Heteroaryl-3,9-Diazabicyclo[3.3.1]Nonane Derivatives as Nicotinic Acetylcholine Receptor Agonists
- 专利标题（中）： 3-杂芳基-3,9-二氮杂双环[3.3.1]壬烷衍生物作为烟碱乙酰胆碱受体激动剂
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申请号： US12087004申请日： 2007-02-09
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公开(公告)号： US20090005388A1公开(公告)日： 2009-01-01
- 发明人: Dan Peters , Daniel B. Timmermann , Gunnar M. Olsen , Elsebet Ostergaard Nielsen , Jeppe Kejser Christensen
- 申请人： Dan Peters , Daniel B. Timmermann , Gunnar M. Olsen , Elsebet Ostergaard Nielsen , Jeppe Kejser Christensen
- 优先权： DKPA2006001900210 20060210
- 国际申请： PCT/EP2007/051272 WO 20070209
- 主分类号： A61K31/4985
- IPC分类号： A61K31/4985 ; C07D471/08 ; A61P25/00
![3-Heteroaryl-3,9-Diazabicyclo[3.3.1]Nonane Derivatives as Nicotinic Acetylcholine Receptor Agonists](/abs-image/US/2009/01/01/US20090005388A1/abs.jpg.150x150.jpg)
摘要：
This invention relates to novel 3,9-diazabicyclo[3.3.1]nonane derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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