发明申请
US20090005575A1 Preparation of diazapentalene derivatives via epoxydation of dihydropyrroles
审中-公开
通过二氢吡咯的氧化制备二氮杂蒽衍生物
- 专利标题： Preparation of diazapentalene derivatives via epoxydation of dihydropyrroles
- 专利标题（中）： 通过二氢吡咯的氧化制备二氮杂蒽衍生物
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申请号： US12069422申请日： 2008-02-08
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公开(公告)号： US20090005575A1公开(公告)日： 2009-01-01
- 发明人: Martin Quibell , Yikang Wang , James Nally , John Paul Watts , Virendar Kumar Agrawal , Michael Standen
- 申请人： Martin Quibell , Yikang Wang , James Nally , John Paul Watts , Virendar Kumar Agrawal , Michael Standen
- 申请人地址： GB Cambridge
- 专利权人： Amura Therapeutics Ltd.
- 当前专利权人： Amura Therapeutics Ltd.
- 当前专利权人地址： GB Cambridge
- 主分类号： C07D487/04
- IPC分类号： C07D487/04
摘要：
The present invention relates to a process for preparing a compound of formula I, wherein R1 is Pg1 or P1′; P1′ is CO-hydrocarbyl; P2 is CH2, O or N-Pg2; and Pg1 and Pg2 are each independently nitrogen protecting groups; (i) reacting a compound of formula II with a dioxirane to form an epoxide of formula III; where X is selected from CN, CH2N3, CH2NH-Pg2, ONH-Pg2, NHNH-Pg2, N(Pg2)NH-Pg2; (ii) converting a compound of formula III to a compound of formula I
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