发明申请
US20090010965A1 Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin
审中-公开
在肉毒杆菌毒素的神经毒性成分的基础上提供温度稳定的肌肉松弛剂的方法
- 专利标题： Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin
- 专利标题（中）： 在肉毒杆菌毒素的神经毒性成分的基础上提供温度稳定的肌肉松弛剂的方法
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申请号： US12154982申请日： 2008-05-29
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公开(公告)号： US20090010965A1公开(公告)日： 2009-01-08
- 发明人: Karl-Heinz Eisele , Harold V. Taylor , Matthias Marx
- 申请人： Karl-Heinz Eisele , Harold V. Taylor , Matthias Marx
- 申请人地址： DE Frankfurt Am Main
- 专利权人： MERZ PHARMA GMBH & CO. KGAA
- 当前专利权人： MERZ PHARMA GMBH & CO. KGAA
- 当前专利权人地址： DE Frankfurt Am Main
- 优先权： EP07010912.9 20070601; EP07020025.8 20071012
- 主分类号： A61K39/02
- IPC分类号： A61K39/02
摘要：
The present invention provides a method for providing a muscle relaxant, wherein said muscle relaxant is a reconstituted solution comprising the neurotoxic component of botulinum toxin free of complexing proteins, which exhibits at least one of the following characteristics, more preferably all characteristics a) to d): a. Stable at storage temperatures above 20° C. b. Stable in the presence of preservatives and/or analgesics c. Resistant against “freeze and thaw”-cycles d. Stable if stored in containers of different material.
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