发明申请
- 专利标题： Mediators of Hedgehog Signaling Pathways, Compositions and Uses Related Thereto
- 专利标题（中）： 刺猬信号途径，作曲和使用的中介者相关
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申请号： US11718470申请日： 2005-11-03
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公开(公告)号： US20090012082A1公开(公告)日： 2009-01-08
- 发明人: Olivin M. Guicherit , Edward Andrew Boyd , Judith Boyd , Shirley Ann Brunton , Stephen Price , John Harry Alexander Stibbard , Colin H. MacKinnon
- 申请人： Olivin M. Guicherit , Edward Andrew Boyd , Judith Boyd , Shirley Ann Brunton , Stephen Price , John Harry Alexander Stibbard , Colin H. MacKinnon
- 申请人地址： US MA Cambridge
- 专利权人： CURIS, INC.
- 当前专利权人： CURIS, INC.
- 当前专利权人地址： US MA Cambridge
- 国际申请： PCT/US05/40054 WO 20051103
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D401/02 ; C07D413/02 ; C07D401/14 ; C07D417/02 ; C07D413/14 ; A61P35/00 ; G01N33/53 ; C07D211/68 ; A61K31/4439 ; A61K31/444 ; A61K31/4545
摘要：
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.
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