发明申请
- 专利标题： PROCESS FOR THE MANUFACTURE OF BENZYLSULFONYLARENES
- 专利标题（中）： 制备苯甲醚的方法
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申请号： US12135350申请日： 2008-06-09
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公开(公告)号： US20090012308A1公开(公告)日： 2009-01-08
- 发明人: Mahmut Levent , Panolil Raveendranath , Sanjay Raveendranath , Vijay Raveendranath , Girija Raveendranath
- 申请人： Mahmut Levent , Panolil Raveendranath , Sanjay Raveendranath , Vijay Raveendranath , Girija Raveendranath
- 申请人地址： US NJ Madison
- 专利权人： Wyeth
- 当前专利权人： Wyeth
- 当前专利权人地址： US NJ Madison
- 主分类号： C07D231/56
- IPC分类号： C07D231/56 ; C07C315/00
摘要：
The present invention provides a process for the manufacture of an arylmethyl-sulfonylarene, R1CH2SO2R2, wherein R1 and R2 are each independently an optionally substituted phenyl or naphthyl group which process comprises reacting an arylmethylhalide, R1CH2-Hal wherein R1 is as defined hereinabove and Hal is Cl, Br or I with a sodium arylsulfinate R2SO2Na wherein R2 is as defined hereinabove in the presence of a base optionally in the presence of a solvent.Also provided is the use of the inventive process in the manufacture of a 3-arylsulfonylindazole 5-HT6 ligand.