发明申请
- 专利标题： Process for preparing bupropion hydrochloride
- 专利标题（中）： 盐酸安非他酮的制备方法
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申请号： US12216513申请日： 2008-07-07
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公开(公告)号： US20090012328A1公开(公告)日： 2009-01-08
- 发明人: Chaogang Wu , Huayou Xiang , Xianghua Yu , Chun He , Fengying Li , Xianghong Shi , Chengyue Lu , Guoliang Chen , Yangxiang Ge
- 申请人： Chaogang Wu , Huayou Xiang , Xianghua Yu , Chun He , Fengying Li , Xianghong Shi , Chengyue Lu , Guoliang Chen , Yangxiang Ge
- 优先权： CN200710069901.6 20070706
- 主分类号： C07C221/00
- IPC分类号： C07C221/00
摘要：
This invention described a synthesis method of bupropion hydrochloride. m-chloropropiophenone was brominated directly with bromine, then aminated with t-butylamine and finally reacted with HCl to obtain crude product of bupropion hydrochloride. Pure product was obtained after recrystallization. This method is convenient and suitable for commercial manufacturing because of low cost of production, high yield, less byproducts and being environmental friendly.
公开/授权文献
- US07737302B2 Process for preparing bupropion hydrochloride 公开/授权日：2010-06-15
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