发明申请
US20090012607A1 METHOD FOR THE PREPARATION OF TUBE-TYPE POROUS BIODEGRADABLE SCAFFOLD HAVING DOUBLE-LAYERED STRUCTURE FOR VASCULAR GRAFT
审中-公开
用于制备具有双层结构的管状多孔生物可降解SCAFFO的方法
- 专利标题: METHOD FOR THE PREPARATION OF TUBE-TYPE POROUS BIODEGRADABLE SCAFFOLD HAVING DOUBLE-LAYERED STRUCTURE FOR VASCULAR GRAFT
- 专利标题(中): 用于制备具有双层结构的管状多孔生物可降解SCAFFO的方法
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申请号: US11952759申请日: 2007-12-07
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公开(公告)号: US20090012607A1公开(公告)日: 2009-01-08
- 发明人: Sang-Heon KIM , Soo Hyun KIM , Eunna CHUNG
- 申请人: Sang-Heon KIM , Soo Hyun KIM , Eunna CHUNG
- 申请人地址: KR Seoul
- 专利权人: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- 当前专利权人: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
- 当前专利权人地址: KR Seoul
- 优先权: KR10-2007-0067907 20070706
- 主分类号: A61F2/82
- IPC分类号: A61F2/82 ; B29C70/32
摘要:
Disclosed herein are a tube-type porous scaffold having a double-layered structure for use as an artificial vascular graft and a preparation method thereof. The method comprises (1) dissolving a biodegradable polymer in an organic solvent and mixing the polymer with a porogen so as to provide a polymer/porogen mixture; (2) coating a cylindrical shaft with the polymer/porogen mixture so as to form an inner porous coating layer; (3) preparing a biodegradable polymer gel by dissolving a biodegradable polymer in an organic solvent; (4) spinning down the biodegradable polymer gel in a non-solvent coagulation bath in which the cylindrical shaft having the inner porous coating layer, obtained at step (2), is immersed and rotated to form gel-phase fibers and allowing the gel-phase fibers to wind around the inner porous coating layer of the rotating shaft so as to form an outer polymer fibrous layer; and (5) separating the double-layered porous scaffold, formed on the shaft, from the shaft and removing the organic solvent and the porogen from the scaffold. Since the porous scaffold has a double-layered structure consisting of an inner porous coating layer containing micropores and a gel-phase outer polymer fibrous layer, it has high pore interconnectivity and mechanical strength, which effectively prevents the leakage of blood, and has high cell seeding and proliferation efficiencies, thereby being useful as a tissue-engineered artificial vascular graft.
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