发明申请
US20090017038A1 Sigma-2 Receptor, Method of Screening of Specific Ligands and Use of the Same in Diagnostic or Therapeutic Methods
审中-公开
Sigma-2受体，筛选特异性配体的方法及其在诊断或治疗方法中的应用
- 专利标题： Sigma-2 Receptor, Method of Screening of Specific Ligands and Use of the Same in Diagnostic or Therapeutic Methods
- 专利标题（中）： Sigma-2受体，筛选特异性配体的方法及其在诊断或治疗方法中的应用
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申请号： US12159818申请日： 2007-01-05
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公开(公告)号： US20090017038A1公开(公告)日： 2009-01-15
- 发明人: Nicola Antonio Colabufo , Francesco Berardi , Roberto Perrone
- 申请人： Nicola Antonio Colabufo , Francesco Berardi , Roberto Perrone
- 优先权： ITRM2006A000007 20060105
- 国际申请： PCT/IB2007/050029 WO 20070105
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07D403/02 ; A61K31/496 ; C07K16/28 ; G01N33/574 ; A61K39/00
摘要：
The present invention relates to the identification, isolation and characterization of the proteins forming the sigma-2 receptor. The invention further relates to the utilization of said proteins for preparing a screening for the sigma-2 receptor, as well as assay of specific candidate ligands to the use of the ligands for setting up diagnostic assays for tumour tissues and for preparing antitumour drugs. Lastly, the isolated proteins are utilized for producing anti-receptor antibodies, which likewise find employ in the diagnosis and therapeutic treatment of neoplasias.
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