发明申请
US20090018080A1 METHODS FOR TREATING VIRAL INFECTION USING IL-28 AND IL-29 CYSTEINE MUTANTS
审中-公开
用于治疗使用IL-28和IL-29 CYSTEINE MUTANT的病毒感染的方法
- 专利标题： METHODS FOR TREATING VIRAL INFECTION USING IL-28 AND IL-29 CYSTEINE MUTANTS
- 专利标题（中）： 用于治疗使用IL-28和IL-29 CYSTEINE MUTANT的病毒感染的方法
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申请号： US12185694申请日： 2008-08-04
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公开(公告)号： US20090018080A1公开(公告)日： 2009-01-15
- 发明人: Kevin M. Klucher , Wayne R. Kindsvogel , Pallavur V. Sivakumar , Katherine E. Henderson
- 申请人： Kevin M. Klucher , Wayne R. Kindsvogel , Pallavur V. Sivakumar , Katherine E. Henderson
- 专利权人： ZymoGenetics, Inc.
- 当前专利权人： ZymoGenetics, Inc.
- 主分类号： A61K38/16
- IPC分类号： A61K38/16
摘要：
IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.