Aspects of the invention include design rule mediated lead placement methods. Also disclosed are methods of using the resultant positioned leads, e.g., e.g., during evaluation of tissue motion, such as of a cardiac tissue motion, e.g., heart wall motion, via electric tomography, are provided. Also provided are devices and systems for practicing the subject methods. In certain embodiments, innovative data processing and display protocols, as well as systems that provided for the same, are provided. The subject methods, devices and systems find use in a variety of different applications, such as cardiac related applications, e.g., cardiac resynchronization therapy, and other applications.