发明申请
US20090022688A1 INHIBITORS OF SERINE PROTEASE, PARTICULARLY HCV NS3-NS4A PROTEASE
审中-公开
丝氨酸蛋白酶特异性HCV NS3-NS4A蛋白的抑制剂
- 专利标题： INHIBITORS OF SERINE PROTEASE, PARTICULARLY HCV NS3-NS4A PROTEASE
- 专利标题（中）： 丝氨酸蛋白酶特异性HCV NS3-NS4A蛋白的抑制剂
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申请号： US12169209申请日： 2008-07-08
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公开(公告)号： US20090022688A1公开(公告)日： 2009-01-22
- 发明人: Luc J. Farmer , Robert B. Perni , Govinda Rao Bhisetti , Keith P. Wilson
- 申请人： Luc J. Farmer , Robert B. Perni , Govinda Rao Bhisetti , Keith P. Wilson
- 主分类号： A61K38/21
- IPC分类号： A61K38/21 ; C07D403/12 ; A61K31/497 ; C07D413/12 ; A61K31/5377
摘要：
The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt, or mixtures thereof, that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are useful as antiviral agents. The invention further relates to pharmaceutically acceptable compositions comprising said compounds either for ex vivo use or for administration to a patient suffering from HCV infection and processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a pharmaceutical composition comprising a compound of this invention.
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