发明申请
US20090028900A1 WEST NILE VIRUSES WITH MUTATIONS IN THE 3' TERMINAL STEM AND LOOP SECONDARY STRUCTURE FOR USE AS LIVE VIRUS VACCINES
有权
在3'终端干细胞和环状二级结构中用于活体病毒疫苗的西尼病毒
- 专利标题： WEST NILE VIRUSES WITH MUTATIONS IN THE 3' TERMINAL STEM AND LOOP SECONDARY STRUCTURE FOR USE AS LIVE VIRUS VACCINES
- 专利标题（中）： 在3'终端干细胞和环状二级结构中用于活体病毒疫苗的西尼病毒
-
申请号： US11629560申请日： 2005-06-14
-
公开(公告)号： US20090028900A1公开(公告)日： 2009-01-29
- 发明人: Lewis Markoff , Li Yu
- 申请人： Lewis Markoff , Li Yu
- 申请人地址： US MD Rockville
- 专利权人： THE GOV'T OF THE USA as represented by THE SECTY, DEPT OF HEALTH AND HUMAN SERVICES
- 当前专利权人： THE GOV'T OF THE USA as represented by THE SECTY, DEPT OF HEALTH AND HUMAN SERVICES
- 当前专利权人地址： US MD Rockville
- 国际申请： PCT/US2005/020737 WO 20050614
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C12N7/00 ; C12Q1/70 ; A61P31/00
摘要：
The invention provides West Nile (WN) viruses and chimeric WN viruses having one or more mutations in the 3′ terminal stem loop secondary structure (3′SL) that results in decreased neurovirulence, methods of making such WN viruses, and methods for using these WN viruses to prevent or treat WN virus infection.
公开/授权文献
信息查询
