发明申请
US20090030006A1 SPIROKETAL DERIVATIVES AND USE THEREOF AS DIABETIC MEDICINE
有权
SPIROKETAL衍生物及其作为糖尿病药物的用途
- 专利标题: SPIROKETAL DERIVATIVES AND USE THEREOF AS DIABETIC MEDICINE
- 专利标题(中): SPIROKETAL衍生物及其作为糖尿病药物的用途
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申请号: US11815074申请日: 2006-01-27
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公开(公告)号: US20090030006A1公开(公告)日: 2009-01-29
- 发明人: Takamitsu Kobayashi , Tsutomu Sato , Masahiro Nishimoto
- 申请人: Takamitsu Kobayashi , Tsutomu Sato , Masahiro Nishimoto
- 专利权人: CHUGAI SEIYAYAKU KABUSHIKI KAISHA
- 当前专利权人: CHUGAI SEIYAYAKU KABUSHIKI KAISHA
- 优先权: JP2005-20901 20050128; JP2005-176690 20050616
- 国际申请: PCT/JP2006/301284 WO 20060127
- 主分类号: A61K31/352
- IPC分类号: A61K31/352 ; A61P3/10 ; C07D493/10 ; A61K31/381 ; A61K31/4433 ; A61K31/498 ; A61K31/404 ; A61K31/4155 ; C07D495/20 ; C07D491/20
摘要:
The present invention provides a compound of Formula (I): wherein R1, R2, R3 and R4 are each independently selected from a hydrogen atom, an optionally substituted C1-C6 alkyl group, an optionally substituted C7-C14 aralkyl group and —C(═O)Rx; Rx represents an optionally substituted C1-C6 alkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted C1-C6 alkoxy group or —NReRf; Ar1 represents an optionally substituted aromatic carbocyclic ring or an optionally mono-substituted aromatic heterocyclic ring; Q represents —(CH2)m-(L)p- or -(L)p-(CH2)m—; m represents an integer selected from 0 to 2, n represents an integer selected from 1 and 2, and p represents an integer selected from 0 and 1; L represents —O—, —S— or —NR5—; and A represents an optionally substituted aryl group or an optionally substituted heteroaryl group, a prodrug thereof and a pharmaceutically acceptable salt thereof, as well as a pharmaceutical preparation or pharmaceutical composition comprising such a compound.
公开/授权文献
- US07767651B2 Spiroketal derivatives and use thereof as diabetic medicine 公开/授权日:2010-08-03