发明申请
- 专利标题: Pharmaceutical composition of telmisartan
- 专利标题(中): 替米沙坦的药物组成
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申请号: US12151818申请日: 2008-05-08
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公开(公告)号: US20090030057A1公开(公告)日: 2009-01-29
- 发明人: Shlomit Wizel , Gershon Kolatkar , Erela Zisman
- 申请人: Shlomit Wizel , Gershon Kolatkar , Erela Zisman
- 主分类号: A61K31/4184
- IPC分类号: A61K31/4184 ; C07D403/10
摘要:
The present invention provides a pharmaceutical composition of telmisartan comprising a) a telmisartan compound, b) a surfactant, c) a basic agent, and d) at least one diluent wherein the composition comprises less than 25% of water soluble diluents. The telmisartan compound is preferably present from about 12.5% to about 15.5%. At least one water insoluble diluent is preferred for use in the pharmaceutical composition in an amount from about 40% to about 70% of the total weight of the pharmaceutical composition. A preferred water insoluble diluent is microcrystalline cellulose. Also described are a pharmaceutical composition comprising telmisartan having a powder X-ray diffraction pattern, methods of preparing such pharmaceutical composition, and a crystalline form of Telmisartan.
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