发明申请
US20090035298A1 METHODS TO TREAT ALZHEIMER'S DISEASE OR OTHER AMYLOID BETA ACCUMULATION ASSOCIATED DISORDERS
审中-公开
治疗阿尔茨海默病或其他AMYLOID BETA累积相关疾病的方法
- 专利标题： METHODS TO TREAT ALZHEIMER'S DISEASE OR OTHER AMYLOID BETA ACCUMULATION ASSOCIATED DISORDERS
- 专利标题（中）： 治疗阿尔茨海默病或其他AMYLOID BETA累积相关疾病的方法
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申请号： US12108065申请日： 2008-04-23
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公开(公告)号： US20090035298A1公开(公告)日： 2009-02-05
- 发明人: David Holtzman , Jae-Eun Kang , John Cirrito , John Csernansky , Hongxin Dong
- 申请人： David Holtzman , Jae-Eun Kang , John Cirrito , John Csernansky , Hongxin Dong
- 申请人地址： US MO St. Louis
- 专利权人： WASHINGTON UNIVERSITY IN ST. LOUIS
- 当前专利权人： WASHINGTON UNIVERSITY IN ST. LOUIS
- 当前专利权人地址： US MO St. Louis
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; G01N33/00 ; A61K31/7088 ; A61K38/16 ; A61K38/00
摘要：
The present invention provides methods for treating amyloid-beta accumulation-associated disorders, such as Alzheimer's disease. The methods comprise modulating the concentration of amyloid-beta in the brain interstitial fluid. In particular, the methods comprise modulating the activity of corticotrophin-releasing factor (CRF), which in turn modulates the concentration of amyloid-beta.
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