发明申请
US20090036448A1 PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF
审中-公开
吡嗪衍生物及其使用相关的治疗方法
- 专利标题： PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF
- 专利标题（中）： 吡嗪衍生物及其使用相关的治疗方法
-
申请号： US10599505申请日： 2005-03-29
-
公开(公告)号： US20090036448A1公开(公告)日： 2009-02-05
- 发明人: Yoshinori Sekiguchi , Kosuke Kanuma , Katsunori Omodera , Thuy-Anh Tran , Graeme Semple , Bryan A. Kramer
- 申请人： Yoshinori Sekiguchi , Kosuke Kanuma , Katsunori Omodera , Thuy-Anh Tran , Graeme Semple , Bryan A. Kramer
- 申请人地址： JP Tokyo US CA San Diego
- 专利权人： TAISHO PHARMECUTICAL CO., LTD.,ARENA PHARMACEUTICALS, INC.
- 当前专利权人： TAISHO PHARMECUTICAL CO., LTD.,ARENA PHARMACEUTICALS, INC.
- 当前专利权人地址： JP Tokyo US CA San Diego
- 国际申请： PCT/JP2005/006582 WO 20050329
- 主分类号： A61K31/506
- IPC分类号： A61K31/506 ; C07D239/48 ; A61K31/5377 ; A61P3/04 ; C07D413/02
摘要：
The present invention encompasses novel substituted pyrimidine compounds of Formula (I): which act as MCH receptor antagonists. These compounds are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.