发明申请
US20090036449A1 Indazolesquaric Acid Derivatives as Chk1, Chk2 and Sgk Inhibitors
审中-公开
吲哚啉酸衍生物作为Chk1，Chk2和Sgk抑制剂
- 专利标题： Indazolesquaric Acid Derivatives as Chk1, Chk2 and Sgk Inhibitors
- 专利标题（中）： 吲哚啉酸衍生物作为Chk1，Chk2和Sgk抑制剂
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申请号： US11887775申请日： 2006-03-21
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公开(公告)号： US20090036449A1公开(公告)日： 2009-02-05
- 发明人: Werner Mederski , Rolf Gericke , Markus Klein , Dieter Dorsch , Norbert Beier , Florian Lang
- 申请人： Werner Mederski , Rolf Gericke , Markus Klein , Dieter Dorsch , Norbert Beier , Florian Lang
- 优先权： DE102005015254.6 20050404; DE102005039066.8 20050818
- 国际申请： PCT/EP2006/002594 WO 20060321
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D231/56 ; C07D403/12 ; C07D413/12 ; A61P9/10 ; A61P35/00 ; A61P3/10 ; A61K31/415 ; A61K31/497
摘要：
Novel squaric acid compounds of the formula (I), in which R, R1, R2, R2′, R2″, R3, B, B′ and X have the meanings indicated in Claim 1, are inhibitors of CHK1 CHK2 and SGK kinases and can be used for the treatment of diseases and complaints such as cancer, diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, generally in fibroses and inflammatory processes of any type.