发明申请
US20090036679A1 METHOD FOR RESOLVING ENANTIOMERS FROM RACEMIC MIXTURE HAVING CHIRAL CARBON IN ALPHA POSITION OF NITROGEN
审中-公开
用于在具有硝酸盐的氨基位置处具有正二氧化碳的混合物的方法
- 专利标题： METHOD FOR RESOLVING ENANTIOMERS FROM RACEMIC MIXTURE HAVING CHIRAL CARBON IN ALPHA POSITION OF NITROGEN
- 专利标题（中）： 用于在具有硝酸盐的氨基位置处具有正二氧化碳的混合物的方法
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申请号： US12278073申请日： 2006-07-31
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公开(公告)号： US20090036679A1公开(公告)日： 2009-02-05
- 发明人: Soon Kil Ahn , Hong Woo Lee , In Taek Lim , Dai Sig Im , Joong Bok Ahn , Jung Hwa Lee
- 申请人： Soon Kil Ahn , Hong Woo Lee , In Taek Lim , Dai Sig Im , Joong Bok Ahn , Jung Hwa Lee
- 申请人地址： KR Seoul
- 专利权人： CHONG KUN DANG PHARMACEUTICAL CORP.
- 当前专利权人： CHONG KUN DANG PHARMACEUTICAL CORP.
- 当前专利权人地址： KR Seoul
- 优先权： KR10-2006-0011226 20060206
- 国际申请： PCT/KR2006/003006 WO 20060731
- 主分类号： C07D411/04
- IPC分类号： C07D411/04 ; C07D217/00
摘要：
Disclosed relates to a simplified method for resolving enantiomers by dissolving a racemic mixture having chiral carbon in α-position of nitrogen and an amino acid to prepare a diastereomeric salt, not using catalyses or enzymes, with enhancing the optical purity remarkably. Moreover, the present invention can prepare the enantiomers in large quantities without using expensive catalysts or without controlling the reaction conditions for the activity of enzymes applied.
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