发明申请
US20090042226A1 Identification and cloning of a full-length human CLNK-related gene, MIST (MAST cell immunoreceptor signal transducer)
有权
鉴定和克隆全长人类CLNK相关基因MIST（MAST细胞免疫受体信号转导子）
- 专利标题： Identification and cloning of a full-length human CLNK-related gene, MIST (MAST cell immunoreceptor signal transducer)
- 专利标题（中）： 鉴定和克隆全长人类CLNK相关基因MIST（MAST细胞免疫受体信号转导子）
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申请号： US12231623申请日： 2008-09-04
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公开(公告)号： US20090042226A1公开(公告)日： 2009-02-12
- 发明人: Juan J. Perez-Villar , Han Chang , Steven B. Kanner , Gena S. Whitney , Yuli Wu , Wen-Pin Yang
- 申请人： Juan J. Perez-Villar , Han Chang , Steven B. Kanner , Gena S. Whitney , Yuli Wu , Wen-Pin Yang
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; C07K16/18 ; C12N5/06 ; C12N9/00
摘要：
The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Novel splice variant forms of human MIST are provided. Methods for screening for modulators, particularly inhibitors, of the MIST protein and use of the human MIST polynucleotide and polypeptide for therapeutics and diagnostics are described.
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