发明申请
- 专利标题: Asymmetric Reduction Method
- 专利标题(中): 不对称还原法
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申请号: US12087092申请日: 2006-12-26
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公开(公告)号: US20090043110A1公开(公告)日: 2009-02-12
- 发明人: Yoshinori Matsumoto , Yuki Takeuchi , Hiroyuki Yamamoto
- 申请人: Yoshinori Matsumoto , Yuki Takeuchi , Hiroyuki Yamamoto
- 申请人地址: JP Matsumoto-shi, Nagano
- 专利权人: KISSEI PHARMACEUTICAL CO., LTD.
- 当前专利权人: KISSEI PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: JP Matsumoto-shi, Nagano
- 优先权: JP2005-374989 20051227
- 国际申请: PCT/JP2006/325875 WO 20061226
- 主分类号: C07D209/44
- IPC分类号: C07D209/44
摘要:
The present invention is to provide a novel method for producing (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid which is useful as a therapeutic agent for diabetes. The present invention relates to a method for producing (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid, which is characterized in that 2-benzylidene-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionic acid is subjected to a catalytic reduction reaction in the presence of an asymmetric catalyst prepared from a pyrrolidinebisphosphine compound (I) represented by the following general formula (I): wherein, R1 represents a linear or branched alkyl group having 1-10 carbon atoms, cycloalkyl group, aralkyl group or aryl group which may respectively have a substituent; and R2 and R3 independently represent an optionally substituted aryl group. The * mark in the pyrrolidine ring shows that the carbon atom at that position has the S configuration, and a rhodium compound.
公开/授权文献
- US07847107B2 Asymmetric reduction method 公开/授权日:2010-12-07
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