Full-duplex communication over a communication link between an initiator operating with an initiator clock and a target operating with a target clock involves, in communication from the initiator to the target: storing data from the initiator in a first FIFO memory with the initiator clock, reading data from the initiator stored in the first FIFO memory, wherein reading is with the target clock transmitting the data read from the first FIFO memory over a first mesochronous link, and storing the data transmitted over the first mesochronous link in a buffer whereby the data are made available to the target. Communication from the target to the initiator includes: transmitting data from the target over a second mesochronous link, and storing the data transmitted over the second mesochronous link in a second FIFO memory, wherein storing is with the target clock, whereby the data are made available to the initiator for reading from the second FIFO memory with the initiator clock signal.