Invention Application
US20090053196A1 Chn-1/Chip-Antagonists For The Treatment Of Muscular Diseases
审中-公开
Chn-1 /芯片拮抗剂治疗肌肉疾病
- Patent Title: Chn-1/Chip-Antagonists For The Treatment Of Muscular Diseases
- Patent Title (中): Chn-1 /芯片拮抗剂治疗肌肉疾病
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Application No.: US11632186Application Date: 2005-07-29
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Publication No.: US20090053196A1Publication Date: 2009-02-26
- Inventor: Ralf Baumeister , Thorsten Hoppe , Britta Spanier , Hanns Lochmuller , Rolf Stucka
- Applicant: Ralf Baumeister , Thorsten Hoppe , Britta Spanier , Hanns Lochmuller , Rolf Stucka
- Applicant Address: DE MUNCHEN
- Assignee: LUDWIG-MAXIMILLIANS-UNIVERSITAT MUNCHEN
- Current Assignee: LUDWIG-MAXIMILLIANS-UNIVERSITAT MUNCHEN
- Current Assignee Address: DE MUNCHEN
- Priority: EP04018128.1 20040730
- International Application: PCT/EP05/08273 WO 20050729
- Main IPC: A61K31/70
- IPC: A61K31/70 ; A01K67/00 ; A61K38/00 ; A61K39/395 ; C12Q1/20
Abstract:
The present invention relates to a pharmaceutical composition comprising an inhibitor/negative regulator/antagonist of the mammalian ortholog of Caenorhabditis elegans CHN-1 and/or of the human CHIP (carboxyl-terminus of Hsc70 interacting protein). Furthermore, the use of said inhibitor/negative regulator/antagonist in medical and pharmaceutical settings is described. In addition, screening methods and tools for the identification of CHIP/CHN-1 inhibitors/antagonists are provided.
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