An apparatus and a method for interference cancellation in a wireless communication system are provided. The method includes receiving channel information from one or more terminals; classifying the terminals into terminals interfered by a neighbor cell and terminals not interfered by the neighbor cell based on the channel information of the terminals; and allocating the terminals interfered by the neighbor cell and the terminals not interfered by the neighbor cell into different resource regions. The transmitter forms the beam taking into consideration the neighbor-cell interference by acquiring the channel information of the neighbor-cell terminals interfered by the transmitter and the scheduled terminal information during beamforming.