An apparatus and method for power saving in a wireless communication system are provided. The method includes performing scheduling considering a channel state of at least one MS located in a service area during an ith scheduling interval, confirming if there is an MS not to be selected at an (i+1)th scheduling interval according to the scheduling result of the ith scheduling interval, and if there is at least one MS not to be selected, controlling the MS not to estimate a channel for scheduling of the (i+1)th scheduling interval.