发明申请
- 专利标题： FINE PARTICULATE PREPARATION COMPRISING COMPLEX OF NUCLEIC ACID MOLECULE AND COLLAGEN
- 专利标题（中）： 包含核酸分子和胶原复合物的精细制备
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申请号： US11909457申请日： 2005-03-24
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公开(公告)号： US20090062184A1公开(公告)日： 2009-03-05
- 发明人: Miho Maeda , Yoshiko Kishimoto
- 申请人： Miho Maeda , Yoshiko Kishimoto
- 申请人地址： JP Osaka JP Tokyo
- 专利权人： Dainippon Sumitomo Pharma Co., Ltd.,Koken Co., Ltd.
- 当前专利权人： Dainippon Sumitomo Pharma Co., Ltd.,Koken Co., Ltd.
- 当前专利权人地址： JP Osaka JP Tokyo
- 优先权： JP2005-086318 20050324
- 国际申请： PCT/JP2006/305845 WO 20050324
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; C07K14/435 ; A61P43/00
摘要：
The present invention relates an additive comprising at least one substance selected from arginine, trometamol, meglumine, lysine, histidine, monoethanolamine, diethanolamine, triethanolamine, succinic acid, citric acid, tartaric acid, lactic acid, and salts thereof, which is useful in the prevention of aggregation of fine particulate complexes of a nucleic acid and collagen, and the production of a preparation comprising particulate complexes of controlled size which is suited for transporting a nucleic acid into cells.
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