发明申请
- 专利标题： Substituted Amino-Pyrimidones and Uses Thereof
- 专利标题（中）： 取代的氨基嘧啶酮及其用途
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申请号： US11577154申请日： 2005-10-14
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公开(公告)号： US20090062282A1公开(公告)日： 2009-03-05
- 发明人: Jeffrey Scott Albert , Don Andisik , James Arnold , Dean Brown , Owen Callaghan , James Campbell , Robin Arthur Ellis Carr , Gianni Chessari , Miles Stuart Congreve , Phil Edwards , James R. Empfield , Martyn Frederickson , Gerard M. Koether , Jennifer Krumrine , Russ Mauger , Christopher William Murray , Sahil Patel , Mark Sylvester , Scott Throner
- 申请人： Jeffrey Scott Albert , Don Andisik , James Arnold , Dean Brown , Owen Callaghan , James Campbell , Robin Arthur Ellis Carr , Gianni Chessari , Miles Stuart Congreve , Phil Edwards , James R. Empfield , Martyn Frederickson , Gerard M. Koether , Jennifer Krumrine , Russ Mauger , Christopher William Murray , Sahil Patel , Mark Sylvester , Scott Throner
- 申请人地址： SE Sodertalje
- 专利权人： AstraZeneca AB
- 当前专利权人： AstraZeneca AB
- 当前专利权人地址： SE Sodertalje
- 国际申请： PCT/SE05/01534 WO 20051014
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D239/22 ; A61K31/513 ; C12N9/99 ; A61P25/28 ; C07D413/10
摘要：
This invention relates to novel compounds having the structural formula Ia or formula Ib below: (Ia, Ib), and their pharmaceutically acceptable salts, tautomers or in vivo hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of Aβ related pathologies such as cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.