发明申请
- 专利标题: 1,4-Substituted Piperazine Derivatives
- 专利标题(中): 1,4-取代的哌嗪衍生物
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申请号: US11887671申请日: 2006-04-05
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公开(公告)号: US20090062293A1公开(公告)日: 2009-03-05
- 发明人: Hiroshi Kawamoto , Toshifumi Kimura , Hisashi Ohta , Akio Sato , Atsushi Satoh , Gentaroh Suzuki
- 申请人: Hiroshi Kawamoto , Toshifumi Kimura , Hisashi Ohta , Akio Sato , Atsushi Satoh , Gentaroh Suzuki
- 优先权: JP2005-109517 20050406
- 国际申请: PCT/JP2006/307691 WO 20060405
- 主分类号: A61K31/496
- IPC分类号: A61K31/496 ; C07D401/04 ; C07D413/04 ; C07D403/04 ; C07D417/04 ; C07D413/14 ; A61P1/00 ; A61P25/00 ; C07D417/14 ; C07D401/14 ; A61K31/501 ; A61K31/506
摘要:
A compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 represents a branched lower alkyl group having from 3 to 9 carbon atoms or the like; R2 represents a 6-membered heteroaryl group having 1 or 2 nitrogen atoms or the like; R3 represents a hydrogen atom, an alkanoylamino group or the like; R4 represents a hydrogen atom, a lower alkyl group or the like; X1 represents an oxygen atom or a sulfur atom; X2 represents an oxygen atom or a single bond; and m indicates an integer of from 0 to 4. This compound has a metabotropic glutamate receptor 1 inhibitory effect, and therefore is useful for the treatment of a brain disorder such as convulsion, acute pain, inflammatory pain, chronic pain, cerebral infraction or transient cerebral ischemic attack, a mental dysfunction such as schizophrenia, and a disease such as anxiety and drug addition.
公开/授权文献
- US08101618B2 1,4-substituted piperazine derivatives 公开/授权日:2012-01-24
信息查询
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