发明申请
- 专利标题: MEDICINAL USE OF RECEPTOR LIGANDS
- 专利标题(中): 受体配体的药物使用
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申请号: US11658307申请日: 2005-07-05
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公开(公告)号: US20090062317A1公开(公告)日: 2009-03-05
- 发明人: Jean-Marie Receveur , Emelie Bjurling , Ann Christensen , Thomas Hoegberg
- 申请人: Jean-Marie Receveur , Emelie Bjurling , Ann Christensen , Thomas Hoegberg
- 申请人地址: DK Hoersholm
- 专利权人: 7TM PHARMA A/S
- 当前专利权人: 7TM PHARMA A/S
- 当前专利权人地址: DK Hoersholm
- 优先权: GB0416728.4 20040727
- 国际申请: PCT/EP2005/007318 WO 20050705
- 主分类号: A61K31/517
- IPC分类号: A61K31/517 ; C07D401/12 ; A61K31/454 ; A61K31/4709
摘要:
Compounds of formula (I) are ligands of the melanin concentrating hormone-1 receptor (MCH-1R), useful in the treatment of diseases responsive to modulation of melanin concentrating hormone (MCH) activity, for example feeding disorders and diseases for which obesity is a risk factor (I): wherein ring B is selected from specific substituted phenyl or benz-fused 5 membered N-containing heterocycles defined in the specification; R, is attached to a ring carbon of ring B, and represents hydrogen, F, Cl, or —OCH3; X is ═CH— or ═N—; L, is —CH2— or —CH2CH2—; L2 is a bond, —CH2— or —CO—; R2 is H or C, —C3 alkyl, or —N(R2) L, —is selected from specific cyclic amino linker radicals as defined in the specification; ring A is selected from specific N-containing heterocyclic rings as defined in the specification.