发明申请
- 专利标题： Acylated Single Chain Insulin
- 专利标题（中）： 酰化单链胰岛素
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申请号： US12282787申请日： 2007-03-12
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公开(公告)号： US20090069215A1公开(公告)日： 2009-03-12
- 发明人: Peter Madsen , Thomas Borglum Kjeldsen , Tina Moller Tagmose
- 申请人： Peter Madsen , Thomas Borglum Kjeldsen , Tina Moller Tagmose
- 申请人地址： DK Bagsvaerd
- 专利权人： Novo Nordisk A/S
- 当前专利权人： Novo Nordisk A/S
- 当前专利权人地址： DK Bagsvaerd
- 优先权： EP06111020.1 20060313
- 国际申请： PCT/EP2007/052289 WO 20070312
- 主分类号： A61K38/28
- IPC分类号： A61K38/28 ; C07K14/62 ; A61P3/10
摘要：
The invention is related to an acylated, single-chain insulin comprising the B- and the A-chain of human insulin or an analogue thereof connected by a connecting peptide, wherein a lysine residue being substituted for the natural amino acid residue in at least one of the positions B20, B21 or B22 in the human insulin B-chain is chemically modified by acylation.
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