发明申请
US20090069293A1 SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF AB PROTEIN PRODUCTION
审中-公开
作为AB蛋白生产抑制剂的苯甲酰胺苯甲酸
- 专利标题： SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF AB PROTEIN PRODUCTION
- 专利标题（中）： 作为AB蛋白生产抑制剂的苯甲酰胺苯甲酸
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申请号： US12254431申请日： 2008-10-20
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公开(公告)号： US20090069293A1公开(公告)日： 2009-03-12
- 发明人: Richard E. Olson
- 申请人： Richard E. Olson
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Pharma Company
- 当前专利权人： Bristol-Myers Squibb Pharma Company
- 当前专利权人地址： US NJ Princeton
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; C07D223/18
摘要：
This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.
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