发明申请
US20090074757A1 Antitumor Combination Comprising Substituted Acryloyl Distamycin Derivatives and Antibodies Inhibiting Growth Factors or Their Receptors
审中-公开
包含取代的丙烯酰基间质霉素衍生物和抑制生长因子或其受体的抗体的抗肿瘤组合
- 专利标题： Antitumor Combination Comprising Substituted Acryloyl Distamycin Derivatives and Antibodies Inhibiting Growth Factors or Their Receptors
- 专利标题（中）： 包含取代的丙烯酰基间质霉素衍生物和抑制生长因子或其受体的抗体的抗肿瘤组合
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申请号： US11887998申请日： 2006-03-29
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公开(公告)号： US20090074757A1公开(公告)日： 2009-03-19
- 发明人: Enrico Pesenti , Marina Ciomei , Maria Cristina Geroni
- 申请人： Enrico Pesenti , Marina Ciomei , Maria Cristina Geroni
- 优先权： EP05102792.8 20050408
- 国际申请： PCT/EP2006/061153 WO 20060329
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61P35/00
摘要：
The present invention provides the combined use of acryloyl distamycin derivatives, in particular α-homo- and α-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and an antibody inhibiting a growth factor or its receptor, in the treatment of tumors. Also provided is the use of the said combinations in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.
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