发明申请
- 专利标题: ENTERIC COATINGS FOR ORALLY INGESTIBLE COMPOSITIONS
- 专利标题(中): 用于不适合组合物的肠溶胶
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申请号: US12019384申请日: 2008-01-24
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公开(公告)号: US20090074944A1公开(公告)日: 2009-03-19
- 发明人: Xueju XIE , Edward Ko , David Ko , Jason Jiang-Chung Ho
- 申请人: Xueju XIE , Edward Ko , David Ko , Jason Jiang-Chung Ho
- 申请人地址: CA Richmond
- 专利权人: VIVA PHARMACEUTICALS INC.
- 当前专利权人: VIVA PHARMACEUTICALS INC.
- 当前专利权人地址: CA Richmond
- 主分类号: A61K9/48
- IPC分类号: A61K9/48 ; C08L1/08
摘要:
A suspendible enteric coating composition for encasing orally ingestible articles wherein the enteric coating composition comprises a pH-dependent polymer selected from a group containing alginates and alginic acids, a pH-independent water insoluble polymer selected from the group comprising ethylcellulose and ethylcellulose-containing compositions, and a plasticizer selected from the group containing triethyl citrate, glycerin, propylene glycol, triacetin, acetylated monoglycerides, dibutyl sebacate, polyethylene glycols, sorbitals, middle chain triglycerides and combinations thereof. A three step method for providing a stable outer enteric coating on an ingestable item comprising a first step of encasing the item with a suspension comprising a mixture of at least a sugar and a microcrystalline cellulose, a second step of then encasing the item with a suspension comprising a mixture of a film-forming polymer and a plasticizer, and a third step of finally encasing the item with the enteric coating composition.
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