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发明申请
US20090078641A1 HOLLOW FIBER MEMBRANE WITH EXCELLENT PERFORMANCE STABILITY AND BLOOD PURIFIER AND METHOD FOR PRODUCING HOLLOW FIBER MEMBRANE 审中-公开
具有优异性能稳定性和血液净化器的中空纤维膜及其生产中空纤维膜的方法

  • 专利标题： HOLLOW FIBER MEMBRANE WITH EXCELLENT PERFORMANCE STABILITY AND BLOOD PURIFIER AND METHOD FOR PRODUCING HOLLOW FIBER MEMBRANE
  • 专利标题（中）： 具有优异性能稳定性和血液净化器的中空纤维膜及其生产中空纤维膜的方法
  • 申请号： US12281862
    申请日： 2007-03-07
  • 公开(公告)号： US20090078641A1
    公开(公告)日： 2009-03-26
  • 发明人: Noriko Monden , Takahito Sagara , Isamu Yamamoto
  • 申请人： Noriko Monden , Takahito Sagara , Isamu Yamamoto
  • 申请人地址： JP Osaka-shi, Osaka
  • 专利权人： TOYO BOSEKI KABUSHIKI KAISHA
  • 当前专利权人： TOYO BOSEKI KABUSHIKI KAISHA
  • 当前专利权人地址： JP Osaka-shi, Osaka
  • 优先权： JP2006-064170 20060309
  • 国际申请： PCT/JP2007/054383 WO 20070307
  • 主分类号： B01D63/02
  • IPC分类号： B01D63/02
HOLLOW FIBER MEMBRANE WITH EXCELLENT PERFORMANCE STABILITY AND BLOOD PURIFIER AND METHOD FOR PRODUCING HOLLOW FIBER MEMBRANE
摘要：
Purpose: To provide a blood purifier having a high water permeability, for use in treatment of chronic renal failure, which is not variable in performance during the treatment, independently of a patient's body condition.Solution: The present invention provides a hollow fiber membrane excellent in performance stability, which has an average thickness of from 10 to 50 μm and an average pore radius of from 150 to 300 Å, and which shows a pure water permeability of 150 to 1,500 mL/m2/hr./mmHg at 37° C., characterized in that the ratio of the overall mass transfer coefficient (Koβ2) of a blood plasma solution of β2-microgloburin to the overall mass transfer coefficient (Komyo) of an aqueous myoglobin solution (i.e., Koβ2/Komyo) is from 0.7 to 1.0.
摘要（中）：

目的：提供具有高透水性的血液净化器，用于治疗慢性肾衰竭，其在治疗期间的性能不变，与患者的身体状况无关。 解决方案：本发明提供性能稳定性优异的中空纤维膜，平均厚度为10〜50μm，平均孔半径为150〜300，纯水透过率为150〜1500mL /m2 / hr./mmHg，其特征在于，β2-微球蛋白血浆溶液的总质量传递系数（Kobeta2）与肌红蛋白水溶液的总传质系数（Komyo）之比 （即Kobeta2 / Komyo）为0.7〜1.0。

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